Effect of Hormone Variations and Other Factors on Symptom Severity in Women With Dystonia
Identifieur interne : 001B38 ( Main/Exploration ); précédent : 001B37; suivant : 001B39Effect of Hormone Variations and Other Factors on Symptom Severity in Women With Dystonia
Auteurs : Katrina A. Gwinn-Hardy ; Charles H. Adler [États-Unis] ; Amy L. Weaver ; Nancy M. Fish ; Stephanie J. NewmanSource :
- Mayo Clinic Proceedings [ 0025-6196 ] ; 2000.
Abstract
Objective To determine if any relationship exists between the severity of symptoms in women with dystonia and female reproductive hormonal variations.Patients And Methods We surveyed 279 women with dystonia seen at Mayo Clinic Scottsdale over a 6-year period (1990-1995), and 204 responded. The women were asked questions regarding their reproductive and menstrual histories and dystonia severity and other questions with an emphasis on possible exacerbating or relieving factors.Results Although in the majority of women hormonal influences had no consistent effect on dystonia symptom severity, 26 (41.9) of 62 premenopausal women noted a change in the severity of their dystonic symptoms in relation to the 3 phases of their menstrual cycle. Other factors that exacerbated dystonia included stress and fatigue, while sleep improved symptoms. Pregnancy, menopause, and hormone replacement therapy had no effect on symptoms.Conclusions Menstrual cycling may result in subjective worsening of dystonia symptoms in some women with dystonia. Further clinical and physiologic evaluation is indicated in such patients, as they may represent an important subgroup of dystonic patients that might yield some clues to the pathophysinlogy of dystonia and to improved treatment strategies.
Url:
DOI: 10.4065/75.3.235
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Effect of Hormone Variations and Other Factors on Symptom Severity in Women With Dystonia</title><author><name sortKey="Gwinn Hardy, Katrina A" sort="Gwinn Hardy, Katrina A" uniqKey="Gwinn Hardy K" first="Katrina A." last="Gwinn-Hardy">Katrina A. Gwinn-Hardy</name></author><author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H." last="Adler">Charles H. Adler</name></author><author><name sortKey="Weaver, Amy L" sort="Weaver, Amy L" uniqKey="Weaver A" first="Amy L." last="Weaver">Amy L. Weaver</name></author><author><name sortKey="Fish, Nancy M" sort="Fish, Nancy M" uniqKey="Fish N" first="Nancy M." last="Fish">Nancy M. Fish</name></author><author><name sortKey="Newman, Stephanie J" sort="Newman, Stephanie J" uniqKey="Newman S" first="Stephanie J." last="Newman">Stephanie J. Newman</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1CF9443058F60BBD12311EE87D94461F5100CC66</idno><date when="2000" year="2000">2000</date><idno type="doi">10.4065/75.3.235</idno><idno type="url">https://api.istex.fr/document/1CF9443058F60BBD12311EE87D94461F5100CC66/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002F95</idno><idno type="wicri:Area/Main/Curation">002C04</idno><idno type="wicri:Area/Main/Exploration">001B38</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Effect of Hormone Variations and Other Factors on Symptom Severity in Women With Dystonia</title><author><name sortKey="Gwinn Hardy, Katrina A" sort="Gwinn Hardy, Katrina A" uniqKey="Gwinn Hardy K" first="Katrina A." last="Gwinn-Hardy">Katrina A. Gwinn-Hardy</name><affiliation><wicri:noCountry code="subField">Ariz</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField">Jacksonville. Fla</wicri:noCountry></affiliation></author><author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H." last="Adler">Charles H. Adler</name><affiliation><wicri:noCountry code="subField">Ariz</wicri:noCountry></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Address reprint requests and correspondence to Charles H, Adler. MD, PhD, Department of Neurology, Mayo Clinic Scottsdale, 13400 E Shea Blvd. Scottsdale</wicri:cityArea></affiliation></author><author><name sortKey="Weaver, Amy L" sort="Weaver, Amy L" uniqKey="Weaver A" first="Amy L." last="Weaver">Amy L. Weaver</name><affiliation><wicri:noCountry code="subField">Ariz</wicri:noCountry></affiliation></author><author><name sortKey="Fish, Nancy M" sort="Fish, Nancy M" uniqKey="Fish N" first="Nancy M." last="Fish">Nancy M. Fish</name><affiliation><wicri:noCountry code="subField">Ariz</wicri:noCountry></affiliation></author><author><name sortKey="Newman, Stephanie J" sort="Newman, Stephanie J" uniqKey="Newman S" first="Stephanie J." last="Newman">Stephanie J. Newman</name><affiliation><wicri:noCountry code="subField">Ariz</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Mayo Clinic Proceedings</title><title level="j" type="abbrev">JMCP</title><idno type="ISSN">0025-6196</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">75</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="235">235</biblScope><biblScope unit="page" to="240">240</biblScope></imprint><idno type="ISSN">0025-6196</idno></series><idno type="istex">1CF9443058F60BBD12311EE87D94461F5100CC66</idno><idno type="DOI">10.4065/75.3.235</idno><idno type="PII">S0025-6196(11)65026-X</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0025-6196</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective To determine if any relationship exists between the severity of symptoms in women with dystonia and female reproductive hormonal variations.Patients And Methods We surveyed 279 women with dystonia seen at Mayo Clinic Scottsdale over a 6-year period (1990-1995), and 204 responded. The women were asked questions regarding their reproductive and menstrual histories and dystonia severity and other questions with an emphasis on possible exacerbating or relieving factors.Results Although in the majority of women hormonal influences had no consistent effect on dystonia symptom severity, 26 (41.9) of 62 premenopausal women noted a change in the severity of their dystonic symptoms in relation to the 3 phases of their menstrual cycle. Other factors that exacerbated dystonia included stress and fatigue, while sleep improved symptoms. Pregnancy, menopause, and hormone replacement therapy had no effect on symptoms.Conclusions Menstrual cycling may result in subjective worsening of dystonia symptoms in some women with dystonia. Further clinical and physiologic evaluation is indicated in such patients, as they may represent an important subgroup of dystonic patients that might yield some clues to the pathophysinlogy of dystonia and to improved treatment strategies.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Arizona</li></region></list><tree><noCountry><name sortKey="Fish, Nancy M" sort="Fish, Nancy M" uniqKey="Fish N" first="Nancy M." last="Fish">Nancy M. Fish</name><name sortKey="Gwinn Hardy, Katrina A" sort="Gwinn Hardy, Katrina A" uniqKey="Gwinn Hardy K" first="Katrina A." last="Gwinn-Hardy">Katrina A. Gwinn-Hardy</name><name sortKey="Newman, Stephanie J" sort="Newman, Stephanie J" uniqKey="Newman S" first="Stephanie J." last="Newman">Stephanie J. Newman</name><name sortKey="Weaver, Amy L" sort="Weaver, Amy L" uniqKey="Weaver A" first="Amy L." last="Weaver">Amy L. Weaver</name></noCountry><country name="États-Unis"><region name="Arizona"><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H." last="Adler">Charles H. Adler</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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